# Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity

> **NIH NIH P20** · MARSHALL UNIVERSITY · 2022 · $117,472

## Abstract

There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at
Marshall University’s School of Medicine (MUSOM). Many of the innumerable health disparities of West
Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At
the epicenter of these disparities, MUSOM is well positioned to address this. Thus, the overall goal of this new
Center for Biomedical Research Excellence (COBRE) application is to promote cellular transport physiology
research in obesity related diseases by the next generation of biomedical investigators and to enhance the
necessary infrastructure to accomplish this at the MUSOM. The Appalachian Center for Cellular transport in
Obesity Related Disorders (ACCORD) will serve as the academic home for this COBRE. It will leverage
existing resources such as the WV IDeA Network of Biomedical Research Excellence (WV-INBRE), excellent
core facilities, and new institutional resources to train the junior investigators. Every COBRE project is
hypothesis-driven; with each addressing a novel cellular transport alteration in a distinct obesity related
condition, and each utilizing innovative complementary state of the art experimental approaches. A
comprehensive and interactive mentoring plan with attention to the individualized needs of each junior
investigator, and outstanding senior investigators as mentors, that is evaluation driven will train the junior
investigators to become independent scientists. Novel hands-on mentoring and networking opportunities will
further enhance the training of junior investigators. In order to sustain these many training opportunities, while
addressing one of the most prevalent diseases, obesity, at the heart of many health disparities in WV/CA and
nationwide, new resources (space, funding and faculty positions) have been committed to ACCORD by the
institution. In turn, ACCORD, to enhance institutional cellular transport in obesity related disorders biomedical
research capacity, will develop new resources as future Cores (e.g. Biostatistics and Study Design and
Mentoring and Workforce Development preCores) and provide pilot funding. This ACCORD COBRE proposal
is critical for WV/CA, as it focuses on a highly significant and extremely timely research problem. It is
innovative because it studies cellular transport abnormalities in obesity related diseases, unique from any other
COBRE. Thus, the novel projects of this COBRE will likely identify novel targets that can potentially be
modeled as new therapeutics to ameliorate and/or prevent obesity related disorders not only in WV/CA, but
across the country.

## Key facts

- **NIH application ID:** 10460412
- **Project number:** 5P20GM121299-05
- **Recipient organization:** MARSHALL UNIVERSITY
- **Principal Investigator:** Soudamani Singh
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $117,472
- **Award type:** 5
- **Project period:** 2018-02-15 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10460412

## Citation

> US National Institutes of Health, RePORTER application 10460412, Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity (5P20GM121299-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10460412. Licensed CC0.

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