# Core Center for Musculoskeletal Biology and Medicine (Overall Application)

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $774,161

## Abstract

The proposed UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) will be an
interdisciplinary consortium of 114 basic and clinical scientists dedicated to understanding the biology and
pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary
collaborations amongst existing, premier research programs at UCSF in order to accelerate translational
research in musculoskeletal science. A fundamental challenge for bench-to-bedside translational research is
the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this
obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced
investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who
actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology and Biomechanics Core;
2) Imaging Core; and 3) Epidemiology, Biostatistics and Study Design Core. These cores will provide research
support and technical training, as well as a venue for new collaborations and an entry point for new members.
The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars
featuring local and visiting scientists, an annual full-day retreat with the External and Internal Advisory and
Boards, and a symposium with a rotating topic relevant to our theme of Systems in Musculoskeletal Biology and
Medicine. Another vital component of the Center is its Pilot/Feasibility grant program. This provides seed money
to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology grant
program will provide funds to Center members for the purpose of utilizing the outstanding specialized research
services available outside the CCMBM at UCSF. Overall, the funding base for the CCMBM is robust, support
from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object
of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of
musculoskeletal disease.

## Key facts

- **NIH application ID:** 10460468
- **Project number:** 5P30AR075055-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Tamara N Alliston
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $774,161
- **Award type:** 5
- **Project period:** 2019-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10460468

## Citation

> US National Institutes of Health, RePORTER application 10460468, Core Center for Musculoskeletal Biology and Medicine (Overall Application) (5P30AR075055-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10460468. Licensed CC0.

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