# The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

> **NIH NIH U24** · UNIVERSITY OF PENNSYLVANIA · 2022 · $322,000

## Abstract

The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective
collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons,
neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials
focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of
Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as
the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8
additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around
Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary
stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a
multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the
burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary
trials of promising clinical interventions for stroke treatment, prevention, and recovery.
The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has
extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the
current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials
among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the
areas of human subjects protections and other regulatory activities, and education and orientation of clinical
and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub
provides ongoing support for data collection and transfer during trial execution, and provides timely feedback
and education about trial results to member specialists and hospitals to encourage translation of research
results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct
and design of clinical trials by providing them with the knowledge and skills necessary for a successful
academic career as independently-funded clinician-scientists.

## Key facts

- **NIH application ID:** 10460589
- **Project number:** 5U24NS107224-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** SCOTT E KASNER
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $322,000
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10460589

## Citation

> US National Institutes of Health, RePORTER application 10460589, The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) (5U24NS107224-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10460589. Licensed CC0.

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