Project Summary The 2022 GRC on the Biology of Host-Parasite Interactions will focus on the most recent molecular and translational advances in parasitic diseases. A wide range of human and veterinary pathogens that cause malaria, toxoplasmosis, trypanosomiasis, leishmaniasis, amoebiasis and worm infections will be emphasized, with the aim of bringing together scientists from all over the globe to share and synthesize knowledge. The ultimate goal will be to improve the fundamental understanding of these parasites as well as to contribute to the design of future control and elimination efforts. A wide range of topics will be covered at the conference, including sexual differentiation and quorum sensing, immunology and immune-suppression, genome instability, parasite motility, dormancy and persistence, molecular biology and gene expression, host cell responses and manipulation by parasites, and metabolism and drug targets. Additionally, the program will also include a session on effective scientific communication with the general public and government officials. The breadth of this meeting is unique in the field, and it is the only recurring meeting that provides an opportunity for investigators working on both worm and protozoal pathogens to interact with immunologists and medicinal chemists. The meeting also provides academic scientists the opportunity to compare approaches with investigators working within the pharmaceutical industry. The program has been designed to cover this broad range of topics and we have commitments from top scientists in the field to attend and speak. In addition, we will select short talks from abstracts, which will broaden diversity. There will also be preceding Gordon Research Seminar (GRS), which offers a unique opportunity for postdocs and graduate students to organize their own conference, to present their work through talks and posters, and to exchange ideas at the forefront of research in a serene but stimulating atmosphere at the Salve Regina University Campus, Newport. Talks for the GRS will be selected from submitted abstracts reporting latest ground-breaking findings. Students, post-docs and early career scientists are strongly encouraged to apply to both the GRC and GRS. Special efforts are being made to raise funds to provide individuals from endemic countries with support.