# Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

> **NIH NIH K01** · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $177,660

## Abstract

Abstract:
Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States.
Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however,
the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after
a VTE is lacking. The overarching goal of the proposed scientific aims is to further our understanding of the
associations of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE
risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor
levels, which are associated with thrombotic event risk. This study will leverage existing data from the robust
Women’s Health Initiative and the Nurses’ Health Studies I and II cohorts in addition to newly collecting data in
the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of
accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE
risk following physical activity using case-crossover methodology, the evaluation of physical activity and
sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical
activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of

## Key facts

- **NIH application ID:** 10461777
- **Project number:** 5K01HL139997-05
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Laura Brienne Harrington
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $177,660
- **Award type:** 5
- **Project period:** 2018-08-19 → 2024-03-10

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10461777

## Citation

> US National Institutes of Health, RePORTER application 10461777, Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk (5K01HL139997-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10461777. Licensed CC0.

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