Abstract The goal of this application is to secure funding for the 2022 FASEB summer research conference (SRC) on “Immunoreceptors and Immunotherapy.” This long-running SRC began in 1987 and has continued to foster a highly interactive community of researchers focused on solving important problems in immunoreceptor and immunotherapy biology. Immunoreceptors play a central role in cancer, autoimmunity and infectious diseases, whilst immunotherapy is the rapidly expanding field focused on meeting these challenges and changing people’s lives in the clinic. The meeting program addresses new directions in the field by featuring the best science related to immune receptor function, immune cell signaling, and the physiology and pathology of immune diseases. We also highlight emerging topics including inhibitory receptors and antibody engineering, along with autoimmunity and immune dysfunction and immunotherapy in cancer. Our speakers represent leaders in the field as well as early- and mid-career investigators. The speakers have been chosen to feature cutting-edge aspects of immunoreceptor and immunotherapy biology, covering the range from basic science to translational applications. The program also includes state-of-the-art technologies in imaging, structural analysis, computational modeling and therapeutic approaches. As such, this meeting brings together scientists from different fields, creating a dynamic and interdisciplinary environment for building networks and developing collaborations. The FASEB SRC provides an ideal format for this meeting, since interactions between participants is guaranteed by the size of the meeting, multiple poster sessions and shared meals. The R13 will support additional opportunities for trainees and young investigators to present at the conference with short talks and poster presentations. Other networking opportunities, including a “meet the expert” luncheon and Career Workshop will further help to foster connections between young investigators and senior researchers. With SRC program, we aim to encourage intensive scientific discussion that promotes new interactions among the international community engaged in immunobiology research.