PROJECT SUMMARY The 2022 Gordon Research Conference (GRC) on Optics and Photonics in Medicine and Biology continues the 55-year proud history of the GRC on Lasers in Medicine and Biology. This GRC is one of the highest rated meetings indicating the quality of the program and the inclusive community. The 2022 conference brings new life to this longstanding meeting with a focus on biophotonics research spanning the full spectrum from basic biology to clinical medicine. An emphasis throughout the conference this year will be on data science, linked to the theme of the Gordon Research Seminar (GRS), a forum to enhance the GRC experience of graduate students and postdoctoral fellows. This conference will bring together an outstanding and diverse group of scientists at the forefront of biophotonics research to stimulate discussion and exchange of ideas. All speakers are encouraged to present new, unpublished research in the tradition of the “off the record” policy of the GRC. The intimate environment provides a unique experience for researchers across all levels to engage in scientific discovery. The mission of the conference is directly in line with the mission of the NIH to improve health by leading the development and accelerating the application of biomedical technologies. In particular, this year's conference is focused on technology and application that is used to advance basic research and medical care. Biomedical imaging is a primary focus of the meeting, particularly the development of optical imaging technologies to improve the detection, diagnosis, and treatment of disease. Photonic technologies enable biomedical research at multiple scales spanning organ level imaging to molecular level sensing. A primary goal of this conference is the professional development and support of junior scientists. This proposal requests funding to support the registration and travel costs of early career investigators, post-docs, and graduate students to attend the GRC and GRS to be held at Bates College in Lewiston, Maine.