Project Summary The Gordon Research Conference (GRC) and Seminar (GRS) on NOX Family NADPH Oxidases is scheduled for May 28 - June 3, 2022, at the Mount Snow Resort, VT, USA. The NOX GRC will feature unpublished cutting- edge work from international experts as well as emerging early-career investigators in this field. The preceding NOX GRS (May 28-29, 2022) will address specific interests and needs of young research trainees, graduate students and post-doctoral fellows, and will include mentoring sessions addressing career opportunities, grantmanship, etc. NOX enzymes are present in all cell types and are major sources of cellular production of reactive oxygen species, and this enzyme family is increasingly implicated in diverse physiological processes, as well as in many disease types. The NOX research field is advancing rapidly with exciting new developments in NOX biochemistry and structural biology, mechanisms of molecular signaling, genetic associations with disease pathology, and therapeutic developments. The biennial NOX Gordon Conference is firmly established as the premier forum for the presentation and discussion of the latest advances in the field in a highly collegial, collaborative, and informal atmosphere. The program for the 2022 NOX GRC was developed around the theme "NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease", seeking to integrate the NOX research field with rapidly emerging research areas of redox signaling and metabolism. The 2022 NOX GRC Chair (Albert van der Vliet, University Vermont, USA) and Vice-Chair (Marie-Jose Stasia, University Grenoble Alpes, France), along with the 2022 NOX GRS Chairs (Dina Vara and Carmen Veith), have solicited extensive input from a Program Advisory Committee composed of 14 prominent NOX investigators and through informal communications to cover the most exciting new developments and expand the program scope. The meeting will start with a Keynote Session that addresses the discovery and evolution of the NOX enzymes and their general role in redox biology, followed by 8 cutting-edge sessions that will address specific aspects of NOX biochemistry and biology, including NOX structural biology, novel tools to study NOX function and regulation, new developments in NOX-based cell signaling, interactions with cell metabolism, and the impact of NOX enzymes on antiviral host defense and immune regulation, cell differentiation/stem cell function, and disease pathology. Sessions include 36% female speakers/discussion leaders and 26% junior faculty. Up to 12 short talks will be selected from submitted abstracts to accommodate cutting-edge late-breaking scientific advances and provide speaking opportunities for new investigators. We expect exciting, state-of-the-art presentations, along with ample time for vigorous discussion. Poster sessions will allow extended discussion and active involvement of trainees in a friendly, supportive and informal atmosphere, and will be promoted by ne...