# Limited Competition for Continuation of the MAPP-RN DCC

> **NIH NIH U24** · UNIVERSITY OF PENNSYLVANIA · 2021 · $499,999

## Abstract

Project Summary
This proposal for an Administrative Supplement to the U24 grant for the Continuation of the
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data
Coordinating Core (DCC) is being submitted by the DCC for the MAPP Research Network (MAPP-RN) at
the University of Pennsylvania Perelman School of Medicine. The DCC team will provide additional
services beyond those currently funded as the DCC for the MAPP Research Network, in support of new
Specific Aims 1-5 during the current budget year 14 (BY14). The clinical data, documentation and
descriptions of the biospecimen resources from the MAPP I EPS and MAPP II SPS will be made accessible
for “public facing” exploration via a re-engineered MAPP website (Specific Aim 1), together with a totally new
MAPP DataView toolkit (Specific Aim 3) designed for data visualization and for the conduct of comparative
analyses between, and within, the extensive EPS and SPS cohort data, as well as to conduct advanced
analyses within selected subgroups assembled by aggregating aligned data across both of these two
cohort studies. In addition to implementing final data curation and harmonization across the EPS and SPS
cohort data, the DCC will prepare extensive documentation for simultaneous posting on the new MAPP
website and for deposit to the NIDDK Repository (Specific Aim 2). Furthermore, the DCC will prepare
workshop materials and host MAPP DataView workshops, promoting MAPP data use for new research
investigations (Specific Aim 4). Educational materials designed for investigators and research teams to
maximize the utility of these data resources and to implement specialized statistical procedures
(consensus clustering for baseline subgroup discovery, quantifying clinically meaningful change utilizing
Global Response Assessment (GRA) scores and levels of symptom change, longitudinal functional
clustering for outcome subgroup discovery) applied to MAPP II SPS data will be emphasized. In
particular, the DCC will prepare longitudinal analyses using the Global Response Assessment (GRA), Pelvic
Pain Severity (PPS) and Urinary Symptoms Severity (USS) profiles available within the MAPP II SPS to
identify factors associated with simultaneous improvement in both PPS and USS symptom profiles, in contrast
to patients that improve only in PPS, only in USS, or in neither of PPS or USS (Specific Aim 5).

## Key facts

- **NIH application ID:** 10464136
- **Project number:** 3U24DK082316-14S1
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** J Richard Landis
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $499,999
- **Award type:** 3
- **Project period:** 2021-08-09 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10464136

## Citation

> US National Institutes of Health, RePORTER application 10464136, Limited Competition for Continuation of the MAPP-RN DCC (3U24DK082316-14S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10464136. Licensed CC0.

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