# FASEB Science Research Conference: Protein Kinases and Protein Phosphorylation

> **NIH NIH R13** · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2022 · $3,500

## Abstract

Program Director/Principal Investigator (Last, First, Middle): Toker, A./Bennett, A.
Protein phosphorylation is vitally important in the molecular communications that control cellular state and
activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal
cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study
of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of
research that has driven methodological and conceptual advances and is increasingly contributing to the
development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been
the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by
the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under
development. This strong clinical connection provides an exciting link with translational science.
In this application, we request funds to support attendance of trainees, junior faculty and traditionally
underrepresented groups at the 2022 FASEB Summer Research conference on Protein Kinases and Protein
Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that
brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and
fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal
with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary
venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and
disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein
phosphorylation, in human disease. The 2022 FASEB Science Research Conference on Protein Kinases and
Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to
bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and
medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines
of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists
in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms
that regulate important biological processes and facilitate the identification of critical targets for the diagnosis,
prevention, treatment, and cure of human diseases.
OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

## Key facts

- **NIH application ID:** 10464756
- **Project number:** 1R13CA271499-01
- **Recipient organization:** FEDERATION OF AMER SOC FOR EXPER BIOLOGY
- **Principal Investigator:** Alex Toker
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,500
- **Award type:** 1
- **Project period:** 2022-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10464756

## Citation

> US National Institutes of Health, RePORTER application 10464756, FASEB Science Research Conference: Protein Kinases and Protein Phosphorylation (1R13CA271499-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10464756. Licensed CC0.

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