# Applied Physiology and Mechanisms

> **NIH NIH P30** · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $204,515

## Abstract

Project Summary: RC-2
 Age-related functional decline is accelerated by acute events by disabling conditions (e.g., stroke, hip
fracture, arthritis, peripheral arterial disease) and chronic disease (e.g., cardiovascular disease, diabetes).
These conditions predispose a multi-system decline that severely reduces functional independence and quality
of life. The overarching goal of the UM-OAIC is to accelerate the development of meaningful interventions to
improve disability related functional declines in older individuals. Evidence from studies by UM-OAIC
investigators and others has linked the benefits of exercise to a reduction in the inflammation and endocrine-
metabolic dysfunction that accompany disabling conditions in the older adults. These works inform our
overarching hypothesis that exercise, activity-based, and multi-modal rehabilitation can improve multiple
physiological systems in older mobility-limited individuals which in turn can improve functional performance,
reduce cardiometabolic disease risk, and prevent functional decline. In this renewal, the RC-2 expands its
clinical outcome measures and extends its support to parallel outcome measures in pre-clinical rodent models.
RC-2 will be led by a multi-disciplinary team made up of Drs. Ryan, Katzel and Ward. Specific Aim 1 is to
advance research focused on the mechanisms of functional decline in older persons with disability and the
mitigation of decline with exercise or activity-based or multi-modal rehabilitation strategies. Specific Aim 2 is to
provide mentoring and training to REC Scholars, affiliated faculty, and UM-OAIC researchers in the
performance of aging research relevant to exercise and rehabilitation-based restoration of function and the
prevention of functional declines in older people with chronic disabling diseases. Through RC-2’s support of
REC Scholars, pilot projects, development projects, and external projects, we will advance the UM-OAIC
mission to reduce disability and restore function in older individuals with disabling conditions and translate our
discoveries toward impactful evidence-based interventions.

## Key facts

- **NIH application ID:** 10465182
- **Project number:** 5P30AG028747-17
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** ALICE S. RYAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $204,515
- **Award type:** 5
- **Project period:** 2006-09-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10465182

## Citation

> US National Institutes of Health, RePORTER application 10465182, Applied Physiology and Mechanisms (5P30AG028747-17). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10465182. Licensed CC0.

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