# Duke Claude D. Pepper Older Americans Independence Center

> **NIH NIH P30** · DUKE UNIVERSITY · 2022 · $1,293,007

## Abstract

PROJECT SUMMARY – Overall
Duke Claude D. Pepper Older Americans Independence Center (Duke OAIC)
The Duke OAIC will provide scientific leadership, innovation, interdisciplinary research strategies, translational
approaches, development of early-stage investigators and a collaborative spirit in its theme: to understand and
optimize physiologic reserve and physical resilience in older adults. The specific aims are to advance
knowledge of measures, mechanisms and analysis of reserve and resilience in older adults through an
integrated research program; to develop and evaluate interventions that optimize reserve and resilience in
older adults; to identify and develop the next generation of researchers who will become leaders in aging and
geriatrics research related to the theme; and to support pilot studies that will progress to successful, more
definitive research studies related to the Duke OAIC focus. The experienced Leadership and Administrative
Core will direct OAIC activities. The Center supports a Research Education Component (REC),
Pilot/Exploratory Studies Core (PESC) and three resource Cores: Molecular Measures, Health and Mobility
Measures, and Analysis. The resource cores provide collaborative support to externally funded projects,
developmental projects, REC Scholars and PESC pilot studies. In addition, the Molecular Measures Core will
develop new molecular profiling and testing capabilities to evaluate resiliencies in the setting of stressors,
including SARS-CoV2, and conduct systems analyses to identify biological pathways indicative of resilient
phenotypes. The Health and Mobility Measures Core will identify gaps in reserve and resiliency measures at
the person level, and develop and adapt innovative measurements for related outcomes; and build resiliency
related data science capacity in collaboration with Duke’s Center for Actionable Health Data Science (Forge).
The Analysis Core will develop and disseminate new biostatistical analytic methodologies to advance the study
of reserve and resilience. The REC will deliver an aging research curriculum around promoting reserve and
resilience, while providing multiple opportunities for feedback, networking, and peer support. The PESC will
facilitate the highest caliber pilot studies related to our theme. The Duke OAIC will use innovative approaches
to facilitate career development and research capabilities, including the Data Integration Working Group,
“Pepper Shakers” Networking Events, Intervention Development for Elderly Adults (IDEA) workshops, National
Research Mentoring Network Training Workshop, training workshops on physical function measurement and
accelerometer analysis methods, Health Care Disparities Research Curriculum, Duke Pepper Center Study
Dashboard and inclusion of community representatives in the pilot study selection process.

## Key facts

- **NIH application ID:** 10465205
- **Project number:** 5P30AG028716-17
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Kenneth E Schmader
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,293,007
- **Award type:** 5
- **Project period:** 2006-09-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10465205

## Citation

> US National Institutes of Health, RePORTER application 10465205, Duke Claude D. Pepper Older Americans Independence Center (5P30AG028716-17). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10465205. Licensed CC0.

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