There is a critical need for a user-centered, accessible informed consent toolkit. The purpose of this G08 application is to develop and deploy an accessible informed consent app- based toolkit to support two target audiences: 1) deaf patients who wish to participate in research studies and 2) clinical research coordinators (CRCs) and principal investigators (PIs) who do not have the resources to make their informed consent materials accessible to prospective participants who are deaf. This project is low-risk and high in impact because it builds on the leadership team’s research with the medically underserved Deaf community. Knowledge gained from the proposed activities will therefore have great potential to bring useful, usable resources to deaf signers and who wish to participate in research or clinical trials. Finally, the resulting resources will fill a gap prioritized in Goals 1&2 of NLM's Strategic Plan Goals because the proposed work will support research through information dissemination strategies that enhance information delivery of research participation and informed consent to underserved, overlooked groups such as deaf people who use ASL.