# Improving Sickle cell care in Adolescents & Adults in Chicago (ISAAC)

> **NIH NIH U01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $26,107

## Abstract

Improving Sickle cell care in Adolescents & Adults in Chicago (ISAAC): Project Summary
Many Chicago adolescents and adults with sickle cell disease (SCD): (1) lack longitudinal regular ambulatory
care, (2) infrequently use hydroxyurea and (3) have inadequate pain control. The overall goal of this project is
to improve outcomes of adolescents and adults with SCD by systematically developing, testing, and
implementing multi-level, multi-modal interventions. Implementation science will guide each activity through the
Getting To Outcomes (GTO) application,2 a widely-used accountability implementation framework.3
ISAAC Collaborating Institutions and Targeted Population: The University of Illinois Hospital & Health Sciences
System (UI Health) includes a 495-bed hospital and the largest pediatric and adult referral Sickle Cell Center in
the Midwest. Sinai Health System (SHS) includes the 319-bed Mt. Sinai Hospital, the 160-bed Holy Cross
Hospital and the Sinai Urban Health Institute (SUHI). SUHI is a regional resource for the Community Health
Worker (CHW) training and implementation. These collaborating institutions serve 542 unique SCD patients
age 15-44 years who live in the Chicago area, about 65% of all SCD patients of this age living in Chicago.
Clinical Site Research Team and Advisory Group: The Research Team will be led by adult and pediatric
hematologists, an implementation research scientist, an expert in health systems coordination and population
health, and an epidemiologist with expertise in community health worker (CHW) coordination. Co-investigators
include primary care and emergency department (ED) clinicians, a biostatistician, design and community
based participatory research experts, and a school health specialist. The Advisory Group includes health
system executives and representatives of FQHCs, community organizations, providers, patients, patient
advocacy organizations, public schools, urban transportation center and Illinois Department of Public Health
(IDPH). Many participants are already collaborators in sickle cell projects funded by HRSA, PCORI and IDPH.
Strategy. We will collaborate in the development of the ISAAC Care Plan (regular longitudinal care; use of
hydroxyurea by patients and clinicians; and evidence-based acute pain management in the ED and hospital
ward (“pain passport”)). Implementation of the Plan will be facilitated by technology - an app that provides
patients and providers access to the ISAAC Care Plan in the patient's electronic medical records (EMR)- and
by CHWs during CHW-led home visits to support patient self-management using the ISAAC Care Plan.
Specific Aims - Phase I. 1. Conduct a needs and resources assessment, identifying barriers and
facilitators to the ISAAC Care Plan. 2. Refine and finalize the ISAAC Care Plan based on the needs and
resources assessment. 3. Enroll at least 300 patients age 15-44 years into a Sickle Cell Registry.
Specific Aims - Phase II. 4. Implement the ISAAC Care Plan developed...

## Key facts

- **NIH application ID:** 10465381
- **Project number:** 3U01HL134042-06S1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Victor R Gordeuk
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $26,107
- **Award type:** 3
- **Project period:** 2016-08-05 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10465381

## Citation

> US National Institutes of Health, RePORTER application 10465381, Improving Sickle cell care in Adolescents & Adults in Chicago (ISAAC) (3U01HL134042-06S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10465381. Licensed CC0.

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