The 31st Fungal Genetics Conference will be held at the Asilomar Conference Center, March 15 -20, 2022. This biennial conference is one of the premiere international meetings for fungal biologists. Approximately 900 US and international scientists and students are expected to attend in-person, with virtual attendance a new opportunity available for the first time in 2022. Goals of this biennial meeting are 1) to promote the dissemination of the latest research on all aspects of the biology of fungi with a focus on filamentous fungi and 2) to promote communication and collaboration between Medical Mycologists and those working with other fungal systems. This has led to recruitment of mycologists to Medical Mycology. Understanding the biology of fungi and their host interactions is critical to, and has been successful in, the development of new antifungal therapeutics. The 31st FGC will have four plenary sessions, four sets of concurrent sessions, and three poster sessions. The plenary topics are: Cell Biology and Morphology, Cross-Species Interactions, Evolution and Development, and Signaling and Metabolism. The 28 concurrent session topics are: Human fungal pathogens, RNA and RNAi biology, Symbionts and endophytes, Morphological transitions, Extreme environments, Interactions with prokaryotes and viruses, Circadian rhythms and photobiology, Plant Pathogens, Secondary metabolism and production of useful metabolites, Stress, Chromatin, heterochromatin, and epigenetics, The mitotic spore: development, dormancy and germination, Lipid metabolism and signaling, Natural and experimental diversity, evolution and populations, Interactions with other non-human/plant eukaryotic species, Natural and applied bioconversion (bioremediation, lignin degradation, biofuels), Mycobiomes and their implications, Mating and sexual development, Molecular basis of biotrophy, Speciation, diversity and evolution, Small molecules in communication, Fungal determinants of host response, Fungi in a changing world - climate change, pandemics, Fungicides and antifungals, Coolest tools for fungal biology, From genome to pangenome, Fungal recognition (self and non-self), Systems biology and biomaterials. Four of the twenty plenary session talks are on medically important fungi and 7 of the 28 concurrent sessions have a significant focus on medical mycology. Other concurrent sessions will include talks on medically relevant fungi. The FGC places a strong emphasis on the participation of young scientists and students, particularly those from underrepresented groups. Many have their first opportunity to present their research at a major international conference. Funds are requested to help defray travel and participation costs of students, postdoctoral researchers and some young scientists, and will be distributed on a need basis.