# Coronary Magnetic Resonance Angiography

> **NIH NIH R01** · STANFORD UNIVERSITY · 2022 · $354,120

## Abstract

Project Abstract
The goal of this project is the robust, noninvasive magnetic resonance (MR)
imaging of the proximal coronary arteries in humans. MR is a dynamic modality
that offers enormous flexibility to deal with the considerations involved in
coronary artery imaging, including resolution (spatial and temporal) and motion.
Improvements in MR hardware, pulse sequences, and data processing
algorithms have led to advances in coronary magnetic resonance angiography
(CMRA). However, further improvements in image quality and consistency are
needed to raise CMRA to the level of clinical utility.
The proposed research plan involves the development and evaluation of new
methods for CMRA. Key components include a novel 3D cones trajectory for fast
whole-heart imaging, and high-quality 3D image-based navigators (iNAVs) every
heartbeat for monitoring motion in every region of the heart. Compared to
conventional CMRA methods, non-Cartesian 3D cones scanning offers higher
scan efficiency and improved motion performance in the heart. Compared to
conventional navigator methods, 3D iNAVs provide much greater information
about heart motion during the scan. Major enhancements to CMRA will be
investigated in this project, including those for higher resolution and more robust
motion detection-compensation. Following a period of technical development and
preliminary evaluation, a comparative study of the optimized CMRA method with
x-ray angiography (stenosis and fractional flow reserve measurements) will take
place on patients with suspected coronary artery disease.

## Key facts

- **NIH application ID:** 10466770
- **Project number:** 5R01HL127039-07
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** DWIGHT NISHIMURA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $354,120
- **Award type:** 5
- **Project period:** 2015-09-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10466770

## Citation

> US National Institutes of Health, RePORTER application 10466770, Coronary Magnetic Resonance Angiography (5R01HL127039-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10466770. Licensed CC0.

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