The Mass Spectrometry Core Facility (MSCF) of the Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana facilitates MS-based approaches for the characterization of proteins and small molecules. Under the direction of Dr. Kendal Ryter, and the management of Dr. Eric Schultz, the Core makes available well-maintained equipment and instrumentation that is not normally found within individual laboratories, providing access and training for researchers within the University of Montana as well as other regional research organizations. In order to meet the needs of its research community, the MSCF strives to maintain a state-of-the-art research environment, provide consulting and staff support for MS sample preparation and analysis, and continue to develop new services to stay at the forefront of biophysical and biomedical research. Active outreach programs are utilized to inform the regional research community, encourage use of the MSCF, and foster collaborations with the Core and associated faculty. Through frequent evaluation and consultation with clients, the MSCF ensures that services provided meet or exceed the needs of our researchers, fostering their own innovation, and providing opportunities to incorporate MS-based approaches in future work.