# Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating

> **NIH NIH SC3** · CALIFORNIA STATE UNIVERSITY LONG BEACH · 2022 · $110,625

## Abstract

Project Summary/Abstract
The primary objective of the proposed project is to prepare surface supportive porous inorganic
framework thin films that have superior properties for drug delivery. The second objective, which
helps with the realization of the first one, is to identify and better understand the chemical and
structural features that have the greatest impact on the drug loading and releasing conditions. To
accomplish these objectives, the PI proposes to modify and identify suitable surface platforms
(with specific chemical features) that can be used to attach selective iron-containing metal organic
framework (Fe-MOF) thin films. These biodegradable Fe-MOFs are composed of Fe(III) clusters
and various organic ligands as struts forming three-dimensional porous structures. The organic
nodes can also serve as binding sites to crosslink with functionalized metal substrates. The drug
loading/releasing with surface-supportive Fe-MOF thin films will be examined by spectroscopic
and microscopic methods. We will also evaluate the toxicity and mechanical durability of these Fe-
MOF coatings. The performance of these iron-containing inorganic frameworks as drug carriers
will be studied in vitro using surface techniques. The knowledge acquired from these initial studies
will be beneficial for the future in vivo studies of applying these Fe-MOF thin films as potential
drug-eluting stent coatings. In addition, the project aims to enhance the scientific understanding of
surface and interface interactions between porous hybrid materials and assorted therapeutic
agents. These results will lead to new insights and guide the material design for future drug-
eluting stents. The proposed research activities will provide excellent health-related research-
education opportunities for students in a minority serving institution like ours, which will bring a
significant positive impact to our community.

## Key facts

- **NIH application ID:** 10466877
- **Project number:** 5SC3GM136590-03
- **Recipient organization:** CALIFORNIA STATE UNIVERSITY LONG BEACH
- **Principal Investigator:** Fangyuan Tian
- **Activity code:** SC3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $110,625
- **Award type:** 5
- **Project period:** 2020-09-11 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10466877

## Citation

> US National Institutes of Health, RePORTER application 10466877, Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating (5SC3GM136590-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10466877. Licensed CC0.

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