# University of Kansas Alzheimer's Disease Research Center (KU ADRC)

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2022 · $3,042,561

## Abstract

ABSTRACT: OVERALL
 The University of Kansas Alzheimer's Disease Research Center (KU ADRC) promotes Alzheimer's
Disease and Related Disorders (ADRD) research at local, national, and international levels. Our strengths in
basic and translational mitochondria, lifestyle modification, and prevention research define a metabolism theme
we pursued and refined over the past decade. We boast a sophisticated and mature infrastructure that
advances a better understanding of AD, better care of affected persons, and new treatment interventions. The
KU ADRC will use its intellectual and infrastructure assets this next cycle to drive AD research at a university
vested and investing in our success, and in doing so move the field closer to a cure.
 Our Center moves seamlessly between bench and bedside, both in terms of the research projects we
support, and in the infrastructure required to back investigator projects. Lifestyle intervention research
generates fundamental mechanistic questions we call on wet lab investigators to address, and questions of
clinical implementation and practice are now the focus of dry lab, clinical, and health care delivery
investigators. Research addressing AD's mitochondrial component demonstrate a role for mitochondrial genes
in AD risk, that mitochondria play a critical role in cell proteostasis and protein aggregation, specific links
between mitochondria and AD hallmark proteins, and how to manipulate brain energy metabolism through
lifestyle and pharmacologic approaches. To date these efforts led us to create novel compounds that constitute
a unique therapeutic pipeline, and clinical trial infrastructure that supports actual studies of metabolism
interventions in actual AD patients.
 For the 2021-26 cycle we will use our intellectual and infrastructure assets to address critical gaps in the
AD field, including gaps in fundamental knowledge and care implementation. During this cycle the KU ADRC
will work to (1) Empower innovative AD and brain aging research, education, and clinical programs; (2) Drive
field-defining metabolism research, and (3) Bring practical and novel metabolism-directed therapies to the
bedside and clinic.

## Key facts

- **NIH application ID:** 10466947
- **Project number:** 5P30AG072973-02
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** RUSSELL H. SWERDLOW
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,042,561
- **Award type:** 5
- **Project period:** 2021-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10466947

## Citation

> US National Institutes of Health, RePORTER application 10466947, University of Kansas Alzheimer's Disease Research Center (KU ADRC) (5P30AG072973-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10466947. Licensed CC0.

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