ABSTRACT This proposal requests funds to support the 75th Annual Symposium of the Society of General Physiologists (SGP), entitled “Ion Channels in Context: Structure and Function in Native Cells and Macromolecular Complexes.” The meeting will be held on September 7-11, 2022 at the Marine Biological Laboratory (MBL) in Woods Hole, MA. The SGP symposium has an established reputation as the leading meeting for physiologists, cell biologists, and biophysicists across all career stages and professional arenas. Each year the meeting topic is unique. In this way, SGP Symposiums highlight timely and emerging topics while leveraging a proven logistical structure, excellent administrative support, and an established base of potential attendees. The 2022 conference will bring together approximately 175 scientists and trainees to discuss novel and fundamental research pertaining to ion channel function in the context of native cells. The size of the meeting, and the venue at the MBL allow presentation of a diverse range of research topics within an environment that maximizes interactions between investigators of different career levels and promotes individual discussions. The overarching goal of the 2022 meeting is to highlight emerging concepts and tools that will promote advances in understanding of how ion channels function in cellular environments. Kurt Beam (National Academy of Sciences, University of Colorado) will deliver the endowed SGP “Friends of Physiology” keynote address. His work on excitation-contraction coupling in skeletal muscle embodies the concept of ion channels working within a macromolecular complex to accomplish a coordinated and fundamental physiological process. The meeting organizers and co-PIs, Drs. Catherine Proenza (University of Colorado) and Matthew Trudeau (University of Maryland) are experts in the field of ion channel function and regulation. They have assembled an enthusiastic group of invited speakers who study a wide range of ion channels in different physiological systems. The invited speakers reflect the commitment of the organizers and the SGP to promoting diversity and equality: 49% are women and 24% are under-represented minorities. Invited speakers also include investigators at all career stages (early 22%, mid 24%, senior 54%). Sessions at the meeting will cover channel function in native cells, channel regulation and allostery, and channel function in disease states. An important goal of the meeting is to foster development and provide opportunities for trainees. To these ends, the schedule includes 3 poster sessions, 24 short talks selected from submitted abstracts, and 2 career development workshops. The specific aims of the symposium are (1) To discuss cutting-edge advances pertaining to ion channel function in physiological contexts; (2) To foster new and interdisciplinary conversations and collaborations; and (3) To Promote early-career investigators and enhance diversity.