# CureGN

> **NIH NIH U24** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $140,000

## Abstract

ABSTRACT
Cure Glomerulonephropathy (CureGN) is a National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK)-sponsored, multi-center international consortium established in 2013 to study the natural history of
glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy,
and IgA nephropathy), understand their underlying biology, develop biomarkers to resolve disease
heterogeneity, and ultimately improve therapeutic options. CureGN has made progress in: 1) establishing a
large, ethnically diverse longitudinal observational cohort of glomerular disease patients; 2) creating a rich,
well-curated clinical data set and linked biospecimens; 3) establishing the largest repository of digital kidney
biopsies; and 4) an infrastructure that will facilitate translational and clinical research by core and ancillary
study scientists.
This supplemental funding request is to measure serum antibodies to M-type phospholipase A2 receptor (anti-
PLA2R levels) and thrombospondin type I domain-containing 7A (THSD7A) from the existing biosamples of the
CureGN membranous nephropathy participants. These biomarkers which were not widely clinically available
at the time of CureGN launch have now been identified as key markers for disease pathogenesis, prognosis
and therapeutic monitoring and are essential information for any study analyzing MN. CureGN will use the
Mayo Clinic BioPharma Diagnostics central laboratory which routinely performs these assays for research and
clinical purposes.

## Key facts

- **NIH application ID:** 10467455
- **Project number:** 3U24DK100845-09S2
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** BRENDA W GILLESPIE
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $140,000
- **Award type:** 3
- **Project period:** 2021-08-23 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10467455

## Citation

> US National Institutes of Health, RePORTER application 10467455, CureGN (3U24DK100845-09S2). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10467455. Licensed CC0.

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