HARVARD CENTER FOR WORK, HEALTH AND WELL-BEING: OVERALL SUMMARY This renewal of the Harvard T.H. Chan School of Public Health Center for Work, Health, and Well-being responds to a significant need for understanding of the impact of conditions of work on worker safety, health, and well-being, and translating research findings into policy and practice. The mission of the Center is to protect and promote worker safety, health, and well-being through integrated workplace policies, programs, and practices that foster safe and healthy conditions of work. Building on our systems-level conceptual model centered on the conditions of work, we will expand our focus on social and health disparities, deepen our understanding of contributors to work-related well-being and mental health indicators, and generate and apply research evidence to advance policy and practice recommendations to improve workplace conditions. We will build on well-established productive partnerships among Harvard, Boston College, Northeastern University, Mass General Brigham, Boston University, HealthPartners, and MA Department of Public Health; a new partnership with Massachusetts Institute of Technology; and an array of regional and national employers and stakeholder groups. Our aims focus on four critical areas: (1) Research: The Center will expand the scientific evidence base for protecting and promoting worker safety, health, and well-being through three large and one small research projects, encompassing etilogic, intervention, and surveillance research across healthcare, warehouses, and construction. The planned research includes a new focus on older workers and examines factors associated with thriving from work. (2) Planning and Anticipating Emerging Issues: To accelerate the acquisition and application of research evidence to inform policy and practice, the Center’s Evaluation & Planning Core will be the locus of overall scientific leadership activities. The Center includes a new Emerging Issues Program that will enable the Center to rapidly respond to new research, policy, and capacity-building priorities. (3) Research to Practice and Capacity Building: The Center will advance adoption and implementation of Total Worker Health® (TWH) through dissemination of resources, best practices, and capacity-building approaches to improve conditions of work. The Center will collaborate with stakeholders, dissemination and implementation partners, and other TWH Centers and affiliates to synthesize key findings and provide guidelines and recommendations. The Center will prepare the next generation of transdisciplinary TWH researchers and build capacity for enterprises to implement TWH. (4) Policy: The Center will advance adoption of evidence- based workplace and public policies that foster supportive conditions of work and protect and promote worker safety, health, and well-being. The Center’s Policy Working Group will identify research priorities and opportunities and ensure that researc...