# Immunology Core (Basic Science Core)

> **NIH NIH P30** · DUKE UNIVERSITY · 2022 · $157,663

## Abstract

PROJECT SUMMARY – Immunology Core (Basic Science Core)
The overall goal of the Immunology Core is to provide Duke HIV/AIDS scientists, clinicians, collaborators, and
trainees access to an innovative, state-of-the-art, and standardized repertoire of immunologic assays that can
comprehensively and deeply interrogate the immunologic space in response to HIV-1 infection, vaccination,
co-infections, and cure strategies. The Immunology Core will continue to address gaps in the field. Three key
examples of accomplishments to date are the following: 1) Provided implementation and training of
standardized neutralization, binding, and cellular assays to national and international laboratories, such that
diverse studies across multiple laboratories can now be directly and rigorously compared for advancing the
science to the next phase. 2) Fostered innovation of new assay development and analysis for multiple
simultaneous measurements, significantly advancing the depth and breadth of immunological information (i.e.
global virus panels for neutralization breadth, immune monitoring assays for TB, flu, malaria, and typhoid, PK
and functional ADA assays for broadly neutralizing antibodies, comprehensive array of Fc effector function
assays, Env characterization on infected cells, novel analytical algorithms, and training for flow cytometric
analyses (such as FLowPET) to integrate complex immunological data and multiplex binding breadth assays.
3) Provided scientific training and mentoring to Duke young investigators, resulting in R01 and P01 awards,
high-impact publications, and career development opportunities. 4) Implemented a recharge system to
provide services to the CFAR community. Thus, the Immunology Core investigators have a strong history
together and are uniquely poised to tackle newly emerging gaps in the field of HIV-1 immunology. The Duke
CFAR’s priority areas for innovative research at Duke are supported by the science and technology offered by
the Immunology Core: 1) the ‘Southern HIV Epidemic’, 2) HIV Co-Morbidities and Co-Infections, 3) Latency
and Eradication, 4) Health Disparities, 5) Vaccine Design and Evaluation, 6) Mental Health and Substance
Abuse, 7) the HIV Organ Policy Equity (HOPE) Act, and 8) Emerging Infections. The Immunology Core’s
assay platform and commitment to innovation is ideally suited for support of the Duke CFAR priority areas
and Specific Aims, as well as broadly covering the current and emerging needs of the Duke CFAR community
of scientists and clinicians. As part of the overall Duke CFAR Aims, the Core will provide advanced assays
and technologies to CFAR investigators, provide support and training for early stage investigators, and
support NIH initiatives (PAVEG, HVTN, IMPAACT, HPTN, CHAVI-ID/CHAVD, MIG, CURE, EQAPOL) and
collaborative partnerships with other CFARs.

## Key facts

- **NIH application ID:** 10468103
- **Project number:** 5P30AI064518-18
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** GEORGIA Doris TOMARAS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $157,663
- **Award type:** 5
- **Project period:** 2005-04-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10468103

## Citation

> US National Institutes of Health, RePORTER application 10468103, Immunology Core (Basic Science Core) (5P30AI064518-18). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10468103. Licensed CC0.

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