PROJECT SUMMARY: The chemokine system consists of chemokines, their cognate G-protein coupled receptors and their atypical receptors, which are structurally related but do not couple to G-proteins. It is an unusually diverse and promiscuous network involved in almost every physiological process of jawed vertebrates. The complexity requires studying the system from different viewpoints and with different tools, approaches and techniques. A prominent feature of the chemokine system is to guide cell migration and position cells in specific niches. The 2022 Gordon Research Conference (GRC) on Chemotactic Cytokines: "Orchestrating cell migration and localization in health and disease" is an internationally renowned meeting dedicated to deconvolute the mechanisms and unveil new functions of the chemokine system. This will be the 14th edition of the Chemokine GRC, which has been held every other year since 1994 (except for 2020), when chemokines first emerged as the largest cytokine gene family in the human genome. As in the past, the Chemotactic Cytokine GRC 2022 will attract scientists from diverse biomedical disciplines to discuss the latest unpublished results that will tackle many aspects of chemokine-related research. The proposed program calls on outstanding specialist that will present new findings, new concepts and potential implications, including translational perspectives. Hence, the meeting will cover basic biochemical and biological aspects of chemokines related to their contributions to cell migration, immune function, and their role in inflammation, infection, autoimmunity and cancer. New developments in potential drugs and disease treatment strategies will also be discussed. The GRC will, like at the recent four editions, be accompanied by a satellite Gordon Research Seminar (GRS) on Chemotactic Cytokines. The GRS "Exploring the chemokine system: from structures to functions" is particularly designed for young scientists, graduate students and early postdocs. These next generation scientists will present their work and receive feedback on their research projects from their peers and from a selected panel of senior internationally renowned field experts and at the same time the forum will promote integration and networking within the field of chemokine research. NIH funding is requested to provide partial support for registration of the participants. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in health and disease. The conference will foster the development of new collaborative projects, which will lead to new discoveries and ultimately new therapies and approaches to treat debilitating human pathologies, including inflammatory, autoimmune, infectious diseases and cancer.