We are requesting funds to support the 50th Annual Meeting of the American Aging Association (AGE) that will take place on May 17-20, 2022 in San Antonio, TX. The 50th Annual AGE Meeting will be held in conjunction with the Nathan Shock Centers of Excellence in the Basic Biology of Aging biennial Geroscience Symposium (May 17). The American Aging Association is the only scientific society in the United States focused solely on the biology of aging. The annual AGE meeting is one of the premier meetings in biogerontological research and serves as a critical activity through which AGE advances its mission to promote biomedical aging studies towards increasing the functional life span of humans, keep the public informed on these activities, increase knowledge of biogerontology among health care professionals, and foster the scientific and professional career development of AGE trainees and scientific members. The primary goal of the conference is to convene senior and junior scientists in a forum where the latest discoveries in aging research are discussed and debated, highlight exciting new research in the field, and promote the emergence of new ideas and collaborative activities among participants. The theme for the AGE 50th annual meeting is “Changing the way we age: 50 years of research in the biology of aging”. At this very special occasion of the Association’s 50th anniversary, the 2022 AGE meeting will feature junior and senior participants representing areas of major advances in the field in the first 50 years of AGE. The invited speakers include prominent established scientists, early career investigators, and trainees, all of whom will be selected based on the quality and impact of their science. For the 50th meeting in San Antonio, 9 non-competing oral sessions will be held along with three special lectures, one of which will be open to the general public. Fostering the next generation of biogerontologists is a primary goal of the society; therefore, one of the sessions will be organized in its entirety by the Trainee Chapter of AGE. In addition, a minimum of two speakers in each of the sessions, and usually three or four, will be early career investigators or trainees selected from submitted abstracts. A poster session will be scheduled that will not compete with oral presentations and poster presenters will be given the opportunity to present their posters in a two-minute oral “poster pitch” during the regular sessions. Gender parity will be achieved and approximately 50% of all speakers will be early career or trainees and at least 20% will be from underrepresented minority groups. We expect that the meeting will be held in person with a live-streamed virtual component. The organizers will also be prepared to conduct the meetings virtually or in an in person-virtual hybrid format if needed. We will adhere to established meeting guidelines, including ensuring that day care opportunities and special need access will be provided.