# Post-Injury Platelet Biology: Mechanisms and Outcomes

> **NIH NIH K23** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $199,098

## Abstract

PROJECT SUMMARY/ABSTRACT
This is an application for a K23 award for Dr. Lucy Kornblith, a trauma and surgical critical care fellow at the
University of California, San Francisco and Zuckerberg San Francisco General Hospital. Dr. Kornblith is
establishing herself as a young investigator in patient-oriented research with a translational focus on trauma-
induced coagulopathy and its pathogenesis to improve the care of injured patients. This K23 award will provide
her with the support necessary to accomplish the following goals: (1) to become an expert translational
researcher in post-injury platelet biology as it relates to trauma-induced coagulopathy; (2) to study the drivers,
mechanisms, and outcomes of alterations in post-injury platelet biology; and (3) to develop all the tools necessary
to have an independent translational research career. Dr. Kornblith is supported by a scientific advisory
committee comprised of a multidisciplinary mentoring team of experts: her primary mentor, Dr. Michael Matthay
has extensive expertise in prospective observational studies, basic science methodology critical to this proposal,
and he is an expert in the career development of early stage investigators; co-mentors are Dr. Mitchell Cohen,
a translational researcher who is an expert in the field of trauma-induced coagulopathy, and Dr. Guy Zimmerman,
an expert platelet biologist. Her advisory committee includes Dr. Shibani Pati, an expert vascular biologist, and
Dr. Alan Hubbard, a biostatistician consultant specializing in causal inference in trauma. Trauma-induced
coagulopathy is a central cause of preventable deaths from hemorrhage after injury. The contribution and impact
of altered post-injury platelet biology on trauma-induced coagulopathy is not well understood despite the pivotal
contribution of platelets to normal coagulation and endothelial integrity. The central hypothesis for this proposal
is that severe injury and shock drive altered platelet activation, platelet aggregation, and platelet-endothelial
interactions that are associated with increased rates of transfusion, organ failure, and mortality. Dr. Kornblith will
investigate these causal pathways, mechanisms, and associated outcomes in a prospective observational
trauma cohort through collection of biospecimens and detailed clinical data. This proposal represents an
innovative approach to studying post-injury platelet biology because it incorporates methods that have not
previously been applied together in trauma populations. Dr. Kornblith will determine the phenotypes of
endothelial injury and platelet biology driven by severe injury and shock following trauma (AIM 1), the effect of
post-injury platelets on in vitro endothelial permeability (AIM 2), and the morbidity and mortality associated with
phenotypes of platelet activation, platelet aggregation, and platelet-endothelial interactions following trauma
(AIM 3). The proposal addresses a major gap in our understanding of the role of platelets in...

## Key facts

- **NIH application ID:** 10468672
- **Project number:** 5K23GM130892-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Lucy Zumwinkle Kornblith
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $199,098
- **Award type:** 5
- **Project period:** 2018-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10468672

## Citation

> US National Institutes of Health, RePORTER application 10468672, Post-Injury Platelet Biology: Mechanisms and Outcomes (5K23GM130892-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10468672. Licensed CC0.

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