PROJECT SUMMARY/ABSTRACT The mission of the Metals in Medicine Gordon Research Conference (GRC) is to cultivate a community of multidisciplinary scientists focused on improving human health by translating basic science discoveries in the areas of bioinorganic chemistry, materials, and inorganic nanotechnology to medical application. The 2022 Metals in Medicine GRC will bring together more than 150 scientists and clinicians from around the world in academia, industry and government to discuss the latest developments in the field in the intimate and informal environment of a GRC. The organizers have three specific aims: 1) Showcase how the properties intrinsic to metals and inorganic materials can be leveraged to develop transformative new chemical and nano-scale entities for use in the diagnosis, imaging, and treatment of disease; 2) Highlight the development of new systems and optimization of existing technologies to aid in understanding the roles of metals in the pathological basis for disease and medical treatments; 3) Provide a stimulating and dynamic gathering to engage and inspire young scientists in this evolving field. The theme of the 2022 meeting is “Advancing the use of metal-based compounds and nanotheranostics for personalized medicine.” Aim 1 is addressed by emphasizing the unique features of metals to support human health. Several sessions mix basic science with advanced pre-clinical and clinical evaluation. The program opens with Supramolecular Coordination Complexes for Biomedical Applications, which will feature the latest innovations in nanoscience as it relates to self-assembling molecular systems and nanomaterials as theranostics. Novel Chelation Strategies and Applications for Radionuclides and Contrast Agents focuses on stably complexing metals to bioconjugates for diagnostics (PET and MRI), and for targeted radionuclide therapy. There will be two sessions on metal-based therapeutics (Stimuli-responsive Materials for Therapy and Imaging and Targeted Metal-based Therapeutics). Clinical Advances for Metals in Medicine will discuss metal-based diagnostics and therapeutics that are in early human trials. Aim 2 is achieved with sessions focusing on basic research and early development of new technologies. The role of specific metals in the etiology of disease will be presented in the session Essential Metals in Disease Mechanisms, and the emerging area of Catalysis in Cells highlights advances in this traditional application of metals in an untraditional environment. Novel Metallomics Methods and Tools presents approaches and technologies to detect, quantify, and trace metals and inorganic materials. The Early Career Investigators/Emerging Topics session will complete the program, and supports Aim 3, with an emphasis on encourage early career investigators. Speakers will also be selected from the submitted abstracts, achieving 25% representation from early stage scientists and ensuring that the most exciting new discoveries are p...