SUMMARY The primary goal of this Core is to administer the resources, both financial and participant samples, needed for the successful completion of the Project and Core research aims. Specifically, this core will provide the following services: 1) Provide administrative and budgetary oversight of the Projects and Cores; 2) Plan and arrange for regular team Program leadership meetings and Program scientific meetings; 3) Facilitate the communication and exchange of data between Projects and Cores; 4) Produce and submit annual progress reports, and the final progress report; 5) Assist in the speedy execution of institutional review board applications and material transfer agreements; and 6) Work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. In addition, this Core will work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. The Administrative and Sample Collection Core will facilitate institutional regulatory approval and material transfer agreements.