# Retinoic acid synthesis induced by noncoding dsRNA controls Regeneration

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2022 · $459,994

## Abstract

Project Summary Abstract
The long term objective of the proposed research is to learn what controls whether injuries heal with
scarring/fibrosis versus full regeneration of lost structures. The human health burden of fibrosis and scarring is
enormous and affects every tissue from heart (lost heart function after a myocardial infarction) to lung
(idiopathic lung fibrosis). Enhancing regeneration could prevent for example the almost universal recurrence of
chronic wounds in the exact location where they previously appeared. We use the Wound Induced Hair
Neogenesis (WIHN) model system where in the center of excisional wounds in mice a variable amount of
regeneration occurs and de novo hair follicles form in a recapitulation of embryogenesis. The goal of this grant
is to understand the factors which control the frequency of regeneration. We will directly test the mechanism
and the ability for candidate molecules which enhance regeneration in mice and in human subjects. The results
of this grant promise to help define new treatments and diagnostics to enhance regeneration and wound
healing.

## Key facts

- **NIH application ID:** 10469347
- **Project number:** 5R01AR074846-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Luis Andres Garza
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $459,994
- **Award type:** 5
- **Project period:** 2019-09-25 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469347

## Citation

> US National Institutes of Health, RePORTER application 10469347, Retinoic acid synthesis induced by noncoding dsRNA controls Regeneration (5R01AR074846-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10469347. Licensed CC0.

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