# Project 1: Implications of blood cell heterogeneity for CV disease

> **NIH NIH P01** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $392,801

## Abstract

PROJECT SUMMARY: The contributions of inflammation to ischemic cardiovascular disease has been well
recognized. It is generally thought that monocyte/macrophage components of the innate immune system are
central to the initiation and progression of atherosclerotic disease. Recent developments by others have
suggested that there are specialized subsets of monocytic cells with particular functions and we have
developed systems that can further assess heterogeneity within hematopoietic cells. Our plan is to use the
emerging technologies that permit clonal assessments of heterogeneity to address the question of what
specific subsets of monocyte/macrophages drive atherosclerosis. We will determine if monocyte/macrophages
are born with endowed predisposition to atherogenesis or acquire such features after arrival at an atheroma.
We will define molecular drivers of such functional attributes and test types of interventions targeting
monocyte/macrophages to reduce the risk of progressive atherosclerosis.

## Key facts

- **NIH application ID:** 10469350
- **Project number:** 5P01HL142494-04
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** David T Scadden
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $392,801
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469350

## Citation

> US National Institutes of Health, RePORTER application 10469350, Project 1: Implications of blood cell heterogeneity for CV disease (5P01HL142494-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10469350. Licensed CC0.

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