# Organoid, Mouse Model, and Biomarker

> **NIH NIH P50** · DANA-FARBER CANCER INST · 2022 · $236,694

## Abstract

PROJECT SUMMARY - Core 3: Organoid, Model Systems, and Biomarkers Core
 The overall purpose of the Organoids, Model Systems, and Biomarkers Core of this Dana-
Farber/Harvard Cancer Center Ovarian Cancer SPORE application is to provide core services to the three
projects and to the other cores. The core will be directed by Drs. Alan D’Andrea, Joyce Liu, and Neil Horowitz.
A primary feature of the core is our recent advances in the generation of short-term ovarian cancer organoid
cultures which closely mimic the tumor from which they are derived (Hill SJ, Decker B, Roberts EA, Horowitz
NS, Muto MG, Worley MJ, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R,
Kochupurakkal B, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz
RS, Crum CP, D’Andrea AD. Prediction of DNA Repair Inhibitor Response in Short Term Patient-derived
Ovarian Cancer Organoids. Cancer Discov. 2018 Sep 13. pii: CD-18-0474. doi: 10.1158/2159-8290.CD-18-
0474.). The core is divided into three aims pertaining to 1) the development of infrastructure from HGSC tissue
collection, 2) the use of PDX models to assess drug combinations in vivo, and 3) the use of HGSC organoids
to assess drug combinations in vitro. The core will provide these studies, as well as relevant DNA repair and
apoptosis biomarkers to the clinical trialists in the thee projects. The core will provide 1) ovarian cancer tissue
collection infrastructure for participants in the SPORE, 2) the generation and analysis of short-term ovarian
cancer organoid cultures, and 3) the generation and analysis of murine PDX models of ovarian cancer.

## Key facts

- **NIH application ID:** 10469372
- **Project number:** 5P50CA240243-03
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** ALAN D. D'ANDREA
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $236,694
- **Award type:** 5
- **Project period:** 2020-08-03 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469372

## Citation

> US National Institutes of Health, RePORTER application 10469372, Organoid, Mouse Model, and Biomarker (5P50CA240243-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10469372. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*