# Clinical Core

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2022 · $809,789

## Abstract

PROJECT SUMMARY - CLINICAL CORE
The Clinical Core will establish and maintain a cohort of extensively characterized individuals who have
volunteered to participate in research projects addressing brain aging and dementia. In the next 5-year cycle,
the Clinical Core of the Northwestern ADRC will continue to serve NIA and NAPA priorities for research on
Alzheimer’s Disease and Alzheimer’s Related Dementias (AD/ADRD). At the same time, the Clinical Core will
leverage local research programs within our longstanding theme of heterogeneity of cognitive aging and
dementia, as reflected in the studies of unusually successful brain aging (SuperAging) and non-amnestic
dementias (e.g., primary progressive aphasia). The emphasis on Alzheimer's disease will shift to earlier onset
and pre-symptomatic stages with a view toward prevention trials. The SuperAging projects will explore factors
that promote resilience to aging-related involutional changes and resistance to the emergence of Alzheimer’s
pathology. The primary progressive aphasia program will help to clarify the biological diversity of Alzheimer's
disease and the principles of selective vulnerability in focal brain neurodegeneration.
In the next five years, the Clinical Core will support the following goals:
 1) Maintain a diverse cohort of 500 research participants characterized by the Uniform Data Set (UDS)
 enhanced with center-specific measures, followed annually, and committed to neuroimaging, tissue
 donation and participation in national collaborations through NACC, ADCS, ADGC, NCRAD, and ADNI and
 in local collaborations investigating cognitive aging and dementia.
 2) Promote areas of clinical and basic research where the Northwestern ADRC enjoys a national leadership
 role, such as SuperAging, primary progressive aphasia (PPA) and other FTLD-spectrum dementias, and
 encourage new investigators from outside fields at Northwestern to collaborate on AD/ADRD research.
 3) Promote the 'therapeutic encounter' theme of the ADRC through the support of innovative non-
 pharmacologic interventions and establishment of long-term relationships between ORE Core social
 workers and Clinical Core participants for recruitment and retention.
 4) Sustain a training approach that capitalizes on the multidisciplinary 'centerness' of the Northwestern
 ADRC and that serves the mission of the Research Education Component through the cultivation of an
 environment where trainees from different disciplines (basic and cognitive science, neurology,
 neuropsychology, psychiatry, social work, and neuroimaging) train together in contiguous space.

## Key facts

- **NIH application ID:** 10469448
- **Project number:** 5P30AG072977-02
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** SANDRA WEINTRAUB
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $809,789
- **Award type:** 5
- **Project period:** 2021-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469448

## Citation

> US National Institutes of Health, RePORTER application 10469448, Clinical Core (5P30AG072977-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10469448. Licensed CC0.

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