PROJECT SUMMARY/ABSTRACT – Administrative Core The Administrative Core advances the scientific mission of CAPS by: providing scientific direction, administrative leadership, and a structure for key decision-making functions; developing and implementing strategic plans; monitoring and evaluating progress; and ensuring efficient administrative operation. In this continuing renewal application, we take a Systems Theory approach, recognizing that CAPS is both a highly integrated collection of cores unified to accomplish its mission and a system of processes interacting to maximize productivity. Thus, CAPS's management strategies focus on its capacity to analyze strategic environments, develop and enact tactics in response to environmental demands, and sustain an adaptive and productive organizational culture. By synergizing across cores, CAPS ensures that the “whole is greater than the sum of its parts.” CAPS learns from its experiences and evolves nimbly and dynamically, continually enhancing its capacity to create and respond to scientific, institutional, and funding needs to scale-up HIV science and attend to the critical needs of highly impacted populations. This infrastructure allows CAPS to remain a global resource for the wider HIV community, including scientists and public health and community partners. In this renewal, the Core will leverage its capacities to support research on two themes: (1) co-occurring and multiplicative factors that fuel HIV transmission and poor health outcomes and (2) HIV-related health systems.