# Core C: Sphingolipid Cancer Animal Pathology Core

> **NIH NIH P01** · STATE UNIVERSITY NEW YORK STONY BROOK · 2022 · $213,680

## Abstract

ABSTRACT
The overall objective of the Sphingolipid Animal Cancer Pathobiology (SACP) Shared Resource is to provide the
Project leaders of this Program Project with the knowledge, resources and ability to fully and efficiently utilize
animal models in the execution of their research projects and to advance their preclinical studies. Through the
SACP core, the projects utilize genetically engineered mouse models (GEMM) for the investigation of the
mechanisms involved in carcinogenesis and metastasis, specifically utilizing a unique set of animals with
deletions in genes of sphingolipid metabolism coupled with pathologically-relevant animal models of specific
cancers. Indeed, the SACP has become a national repository for sphingolipid knock out mice, having generated
several of them.
 Preclinical models, specifically animal models, of cancer are invaluable tools for the identification and
validation of novel functions, interventions, therapeutic targets, and biomarkers. Therefore, the Core will provide
the projects with “start-to-finish” expertise in utilizing in vivo models in their research projects. The Core will
assist with i) animal model selection; ii) generation of animal models of carcinogenesis, including the generation
of novel GEMM; iii) development and use of patient-derived xenografts (PDXs) and engraftment of human cells
in vivo; iv) BioBanking of samples for future and/or collaborative studies; and v) access and use of critical relevant
shared resources available throught the Cancer Center and/or University. The SACP Core will provide the
framework for the projects to efficiently and effectively conduct in vivo resarch.
To this end the SACP Core will: Specific Aim 1: Provide investigators with the necessary resources to
implement in vivo models of cancer; Specific Aim 2: Enable the execution of preclinical and translational
models in carcinogenesis, as well as BioBanking of samples; and Specific Aim 3: Advance the impact
of in vivo research through the use of Shared Resources, animal model alternatives, and data
management.
 The services and expertise of the SACP Core will facilitate in vivo research outlined in this proposal and will
provide the expertise to support the Project Leaders. With the incorporation of carcinogenesis models and
GEMM in sphingolipids, this Core is evolving as a unique and enabling Core that is critical for the success of the
Program Projects and their advancement to preclinical studies.

## Key facts

- **NIH application ID:** 10469609
- **Project number:** 5P01CA097132-19
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Ashley Jones Snider
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $213,680
- **Award type:** 5
- **Project period:** 2003-08-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469609

## Citation

> US National Institutes of Health, RePORTER application 10469609, Core C: Sphingolipid Cancer Animal Pathology Core (5P01CA097132-19). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10469609. Licensed CC0.

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