# The UNC Core Center for Clinical Research: Phenotyping and Precision Medicine Resource Core

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $251,902

## Abstract

ABSTRACT – RESOURCE CORE 
The overall goal of the UNC CCCR is to enhance the design and conduct of clinical studies in 
Rheumatic and Musculoskeletal Diseases (RMDs) with a focus on osteoarthritis (OA), a 
particular strength of our research community. The Phenotyping and Precision Medicine 
Resource Core will provide critical services to our research community that broadly 
include: 1) key scientific expertise and analytic resources needed for prognostic phenotyping 
(predicting outcomes by specific subgroups, e.g. “progressors” versus “non-progressors”) and 
prescriptive phenotyping (predicting response to specific interventions) using clinical datasets, 
and 2) guidance and advice to investigators on phenotypic considerations (such as choice of 
input and outcome variables) in order to enhance the design, implementation, and interpretation 
of new clinical studies and trials. Like many chronic conditions, RMDs, including OA, are not 
single diseases but rather heterogeneous conditions consisting of multiple phenotypes that 
differ in their underlying pathobiological mechanisms. If not taken into consideration, these 
differences result in the testing of interventions designed to address specific mechanisms of 
action in the “wrong” patients. Successful treatments for RMDs therefore need to be targeted to, 
and tested in, specific subgroups or subtypes that share distinct underlying pathobiological, 
psychosocial and pain mechanisms, consistent with the goal of precision medicine. The 
Phenotyping and Precision Medicine Resource Core will work in conjunction with the 
Methodology Core to provide services that will greatly enhance study design and add 
value to a wide spectrum of ongoing, completed, and planned clinical studies through 
the following aims: Aim 1. Provide consultative advice and analytical services for prognostic 
and prescriptive phenotyping for investigators interested in defining subgroups within new or 
ongoing clinical studies in OA or other RMDs, including ancillary studies and studies in the 
planning stages. Aim 2. Apply innovative strategies for phenotyping and precision medicine by 
leveraging data collected in selected clinical studies from our research community, adding value 
to those studies, facilitating external validation and informing future studies. Aim 3. Encourage 
broader implementation of phenotyping and precision medicine approaches for RMDs through 
education and dissemination of the methodologies to local, national, and international research 
communities. A resource core dedicated to phenotyping and precision medicine will greatly 
benefit the research community that will be supported by the CCCR, make a significant impact 
on the field of clinical RMD research, and ultimately on the lives of people suffering from these 
chronic and disabling conditions.

## Key facts

- **NIH application ID:** 10469655
- **Project number:** 5P30AR072580-04
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** RICHARD F LOESER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $251,902
- **Award type:** 5
- **Project period:** 2019-09-11 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469655

## Citation

> US National Institutes of Health, RePORTER application 10469655, The UNC Core Center for Clinical Research: Phenotyping and Precision Medicine Resource Core (5P30AR072580-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10469655. Licensed CC0.

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