PROJECT SUMMARY/ABSTRACT PREMIER, the UCSF Precision Medicine in Rheumatology Center (P30), provides critically important resources and expertise to enable cutting-edge research to advance precision medicine in the rheumatic diseases. PREMIER brings together clinical expertise, defined patient cohorts, state-of-the-art immunophenotyping and genomic technologies with experts in bioinformatics and integrative analyses. This infrastructure facilitates collaborative studies that can integrate the large amounts of clinical and molecular data needed to gain a more fundamental understanding of the biology driving the heterogeneity of clinical phenotypes and treatment responses among individuals with rheumatic disease. PREMIER seeks to lower the barriers to pursuing rheumatology research by providing access to relevant resources along with the expertise to use them appropriately. Our Center includes three Resource Cores that will each provide consultation to guide investigators in study design, analysis, and access to significant expertise and assistance in forming the collaborations needed. The Clinical Data and Informatics Core (CDI), directed by Dr. Jinoos Yazdany, will provide clinical research and informatics services including access to large rheumatic diseases databases, biospecimens and curation of electronic health record data for research discovery; the Genomic Technology Core (GT), co-directed by Drs. Jimmie Ye and Walter Eckalbar, will develop novel genomic technologies and institute specialized workflows and analytic pathways designed for the study of rheumatic diseases; and the Integrative Bioinformatics Core (IB), co-directed by Drs. Marina Sirota and Gabriela Fragiadakis, will address investigator needs for advanced bioinformatics expertise, particularly with regard to single cell analytics, multi-omic integrative analysis, and use of publicly available data. PREMIER’s Administrative Core is led by Dr. Mary Nakamura (Director) and Dr. Jinoos Yazdany (Associate Director) and provides leadership and organizational oversight to the Center. The Core includes a significant enrichment program involving seminars, an annual symposium, workshops led by the Resource Cores, a mentoring program, and a grant program including Development and Feasibility Pilot grants and Core Usage Grants. PREMIER leverages a number of significant UCSF and divisional resources that are highly synergistic with the services offered in PREMIER Resource Cores. Given our track record and deep commitment to innovation, PREMIER is poised to attract new investigators and further advance rheumatology research towards the ultimate goal of improving diagnosis and treatment of rheumatic disease through the detailed elucidation of underlying disease mechanisms.