# Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant

> **NIH NIH P20** · CASE WESTERN RESERVE UNIVERSITY · 2021 · $398,550

## Abstract

Overall Summary/Abstract
The Case Cancer Disparities P20 proposal provides for planning and development of a Specialized Program of
Research Excellence (SPORE) in cancer health disparities. This proposal places an emphasis on colon
adenoma, precursor lesion of colorectal cancer (CRC), and on breast cancer, which are the two leading
causes of cancer death in the United States, and of which, racial disparities persist and are widening. This
proposed P20 program builds on the resources of the Case Comprehensive Cancer Center to propose two
cutting edge translational Research Projects that use multi-level risk assessment approaches for examining
racial difference and epigenetic aging in the development of early colon neoplasia (Project 1) and use systems
biology approaches for interrogating molecular mechanisms underlying racial disparities in triple negative
breast cancer (TNBC) response to treatment and survival (Project 2). These two Research Projects each are
built upon substantial preliminary data, cutting edge technology and methodology, and enabling patient cohorts
and tissues to test novel hypotheses with high translational significance. This P20 program will further develop
a comprehensive infrastructure for catalyzing a robust Developmental Research Program (DRP) that extend
our efforts to other cancers and socioeconomic, demographic and behavioral factors contributing to cancer
disparities. A series of 2 core resources support these projects and also establish a strong programmatic
infrastructure for transdisciplinary translational research in cancer health disparities. The proposal brings
together a highly transdisciplinary team of investigators that work collaboratively through every stages and
aims of the proposed research studies to accomplish the translational goal of this P20 application.

## Key facts

- **NIH application ID:** 10469702
- **Project number:** 3P20CA233216-03S1
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Nathan A. Berger
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $398,550
- **Award type:** 3
- **Project period:** 2018-09-18 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10469702

## Citation

> US National Institutes of Health, RePORTER application 10469702, Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant (3P20CA233216-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10469702. Licensed CC0.

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