# Cancer Prevention and Control Research Program

> **NIH NIH P30** · UNIVERSITY OF KENTUCKY · 2022 · $32,499

## Abstract

PROJECT SUMMARY/ABSTRACT 
 Markey Cancer Center's (MCC) Cancer Prevention and Control (CP) Research Program unites highly 
complementary strengths in the areas of population-based research and community-based cancer control 
research with the overarching goal of reducing cancer disparities in Kentucky with an emphasis on the state's 
Appalachian and rural populations. Kentucky has the highest overall cancer incidence and mortality rates 
among all 50 United States. Alarmingly, the cancer incidence and mortality rates in Appalachian Kentucky are 
far higher than the rates for the non-Appalachian area of the state. These elevated rates are driven by a variety 
of underlying factors including low socioeconomic status, low educational attainment, high risk behaviors, 
cultural barriers, and environmental exposures. Strengths of the CP program include studies focused on 
uncovering the role environmental exposures play in Kentucky's high cancer incidence rates, testing 
intervention programs that address unique cultural barriers, and smoking cessation policy development 
initiatives. CP program members are also national leaders in developing population-based methods and 
measures that facilitate inter-programmatic cancer research. The CP program combines these strengths to 
address 3 thematic areas: identification of social, cultural, behavioral, genetic and environmental factors that 
contribute to the elevated cancer incidence and mortality rates (Theme 1); design, testing, implementation and 
evaluation of intervention strategies that address identified risk factors (barriers) and reduce the cancer burden 
(Theme 2); and development of population-based methods and measures that facilitate inter-programmatic 
cancer research directed at more precisely identifying the distribution of treatment patterns and biomarkers in 
the population (Theme 3). Most recently, the CP program recruited 2 National Cancer Institute-funded cancer 
molecular epidemiologists to build on its unique research resources. The current 28-member CP team draws 
from 5 colleges and 12 departments at the University of Kentucky, thus promoting active interdisciplinary 
translational research. CP productivity is reflected by total annual external cancer-related funding of over 
$9.7M ($6.7M annual direct costs) and 245 total publications in the current funding period, 30 (12%) of which 
are inter-programmatic, 83 (34%) intra-programmatic and 162 (66%) inter-institutional. CP research 
encompasses all segments of the cancer control continuum: prevention, early detection, treatment and 
survivorship. CP studies address a number of cancer sites including those that disproportionately contribute to 
Kentucky's high cancer burden (i.e. lung, colon, breast and cervical cancers). Thus, the CP program is integral 
to achieving the overall MCC mission to reduce cancer morbidity and mortality in the Commonwealth.

## Key facts

- **NIH application ID:** 10470110
- **Project number:** 5P30CA177558-10
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Jerod L Stapleton
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $32,499
- **Award type:** 5
- **Project period:** 2013-07-08 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10470110

## Citation

> US National Institutes of Health, RePORTER application 10470110, Cancer Prevention and Control Research Program (5P30CA177558-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10470110. Licensed CC0.

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