# Transition Metal-Radical Hybrid Methods for Organic Synthesis

> **NIH NIH R01** · UNIVERSITY OF TEXAS DALLAS · 2022 · $319,800

## Abstract

Project Description
The proposed program aims at the development of a new synthetic platform for controlled selective
functionalizations of aliphatic molecules possessing unreactive C(sp3)–H bonds. The existing synthetic
methods toward complex molecules and pharmaceuticals mostly rely on employment of pre-functionalized
substrates. Employment of non-functionalized saturated hydrocarbon groups is much more appealing as these
moieties are much more abundant and cheap. Moreover, the aliphatic C(sp3)–H bonds are often present in
complex biologically important molecules and pharmaceuticals, and thus their selective functionalization offers
a powerful tool for late stage modifications. The few existing methods for functionalization of saturated groups
are not general, as the functionalization site is usually substrate-controlled. Also, these methods operate under
acidic conditions and/or employ external oxidants, which limits the substrate scope. Thus, mild regio- and
stereo-controlled functionalization of saturated groups remains a holy grail in modern synthetic chemistry. We
propose the development of a novel visible light-induced transition metal-radical hybrid catalytic methodology
for regiocontrolled, mild, and external oxidant-free functionalizations of saturated groups. The site of
functionalization will be controlled by a designed tool-kit of temporary auxiliaries, which potentially in one-pot
fashion will be routinely installed onto substrate and removed from the product. The feasibility of a successful
development of this project is supported by a vast amount of preliminary results obtained in our lab. The
proposed project consists of three major Sections: 1. Development of efficient catalytic systems for
functionalization of aliphatic groups. 2. Development of a tool-kit for general efficient and site-controlled
proximal and remote functionalizations of various organic molecules. 3. Implementation of novel reactivity of
transition metal-radical hybrid complexes under development toward new transformations including C(sp3)–H
functionalizations and cascade reactions.

## Key facts

- **NIH application ID:** 10470374
- **Project number:** 5R01GM120281-07
- **Recipient organization:** UNIVERSITY OF TEXAS DALLAS
- **Principal Investigator:** VLADIMIR GEVORGYAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $319,800
- **Award type:** 5
- **Project period:** 2017-04-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10470374

## Citation

> US National Institutes of Health, RePORTER application 10470374, Transition Metal-Radical Hybrid Methods for Organic Synthesis (5R01GM120281-07). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10470374. Licensed CC0.

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