# MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7

> **NIH NIH N01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $913,852

## Abstract

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and
progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men
and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding
period of MESA, 6,814 participants were recruited from six field centers during 2000-2002 and
examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac
MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial
index measurement, and retinal photography. A number of other variables including abdominal aortic
CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and
putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental
characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of
selected components were repeated over five subsequent examinations spanning approximately 16
years and the cohort has been continuously followed for clinical CVD events since the baseline
examination.
This proposal is written in response to the NHLBI RFP (No. 75N92020D00003, Multi-Ethnic Study of
Atherosclerosis (MESA) Exam 7- Task Area B) that seeks to enable a limited reexamination by the
MESA field centers of MESA participants. Task Area B will involve protocol development and
finalization, exam preparation activities, a limited re-examination of all surviving and willing MESA
participants from the field center, and close-out activities for Exam 7. The recruitment goal for Exam 7
is approximately 3,000 participants across all field centers. The performance of Exam 7 will allow
continued scientific collaborations. which will contribute to the following MESA IV scientific objectives:
1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in
informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk
factors or interactions among factors that inform disease pathophysiology.
The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI
contract. These studies will be operationally integrated into the main study, and the data will be shared
across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The
study’s data will be provided to interested investigators through a defined process that encourages
maximum data utilization while protecting participant confidentiality.

## Key facts

- **NIH application ID:** 10470558
- **Project number:** 75N92020D00005-0-759202100001-1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** KAROL WATSON
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $913,852
- **Award type:** —
- **Project period:** 2021-05-19 → 2023-11-21

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10470558

## Citation

> US National Institutes of Health, RePORTER application 10470558, MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7 (75N92020D00005-0-759202100001-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10470558. Licensed CC0.

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