# Animal Core

> **NIH NIH P01** · UNIVERSITY OF COLORADO DENVER · 2022 · $615,481

## Abstract

The primary goal of the Animal Core is to provide accurate hemodynamic characterization of pulmonary
vasoconstriction and vascular remodeling in relevant models of PH of projects 1-4. As described in the specific
aims and tasks of the Animal Core, we will provide: (1) all the necessary support for the PH animal models that
PPG investigators will utilize and monitor the hemodynamic progression of PH; (2) state of the art
hemodynamic equipment and experts trained in all aspects of its use; and (3) Support PPG investigators in
breeding transgenic mice as well as animal euthanasia and tissue collection and organ harvest to insure the
highest integrity of samples for molecular studies. The Animal Core is perfectly situated to support the mission
of the PPG. It leverages fully equipped state of the art equipment and instrumentation to capture hemodynamic
and heart function in a variety of animal species (mice, rats, calves etc.). This includes Millar and SciSense
solid-state catheters, echocardiography, dye dilution methods and noninvasive monitoring of blood pressures
(tail cuff; Harvard apparatus) and blood gases. The Animal Core leadership, Drs. Irwin and Stenmark, have a
proven track record and national reputations for capturing hemodynamic signals in a variety of hypoxic animal
models. The Animal Core staff are proven experts in: (1) animal catheter placements; (2) operating solid-state
and fluid filled transducer systems;(3) evaluating echocardiography images; (4) animal handling and
euthanasia and; (5) tissue and organ collection. Thus, we have the expertise to ensure the integrity of data
collection from the actual inception of the animal study, during chronic hypoxic exposure and serial
hemodynamic data acquisition, and finally during tissue and organ harvest after animal euthanasia. The Animal
Core will integrate, strengthen and synergize with the projects, and with the other Cores as well, thus providing
the ability to significantly increase the overall human relevance of the findings of each project.

## Key facts

- **NIH application ID:** 10470733
- **Project number:** 5P01HL152961-03
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** DAVID Charles IRWIN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $615,481
- **Award type:** 5
- **Project period:** 2020-08-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10470733

## Citation

> US National Institutes of Health, RePORTER application 10470733, Animal Core (5P01HL152961-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10470733. Licensed CC0.

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