# Study of Latinos (SOL) Ojos

> **NIH NIH UG1** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 · $2,319,560

## Abstract

PROJECT SUMMARY/ABSTRACT
This application proposes an ancillary eye study to the Hispanic Community Health Study/Study of Latinos
(HCHS/SOL). HCHS/SOL is a prospective, population-based, multicenter cohort, funded by the National Heart,
Lung, and Blood Institute (NHLBI) and 6 other National Institutes of Health (NIH) Institutes, that is designed to
1) assess disease burden; and, 2) address cardiovascular disease (CVD), stroke, asthma, chronic obstructive
pulmonary disease, sleep disorders, dental caries and periodontal disease, hearing impairment, diabetes,
kidney and liver disease, and cognitive impairment. This landmark study, the largest ever conducted in
Hispanics/Latinos, constitutes a national resource of extensive, high-quality phenotypic and genotypic data.
Participants include those of Mexican, Cuban, Dominican, Puerto Rican, Central and South American, and
Other origins. HSHC/SOL recruited 16,415 participants for Visit #1 (2008-2011); data collection for Visit #2
(2014-2017) concluded 12/17 (Chicago and Miami Field Centers: 82.3% participation rate); and, NHLBI
contracted HCHS/SOL Visit #3 (2019-2022) funding to serve as a platform for ancillary studies. We will recruit
and perfom a detailed eye exam on 2500 HCHS/SOL participants from Chicago and Miami aged ≥40 years to
coincide with Visit #3. The HCHS/SOL Coordinating Center will provide direction in oversampling older adults
to maximize disease detection efficiency, with sampling weights reflecting probabilities of selection to maintain
accurate prevalence rates. Latinos of diverse backgrounds as in HCHS/SOL represent a rich sociocultural and
genetically admixed group, inheriting a mixture of European, Native American, and African ancestry from
populations previously isolated. As such, the HCHS/SOL Eye Study will represent the first highly admixed eye
epidemiology cohort. This heterogeneity and intrinsic variability, essential in basic and clinical research,
innovatively positions the HCHS/SOL Eye Study to assess important etiologic pathways amid prevalent risk
factors and outcomes that cannot be assessed with homogenous cohorts. We propose to collect high-quality
eye outcome data, identical to National Eye Institute (NEI)-funded population-based cohorts, which will allow
the eye epidemiology community to, for the first time, assess novel hypotheses associated with systemic
disease in a well-characterized, diverse cohort. The HCHS/SOL Eye Study is designed to 1) assess and
compare the 2010 age-standardized prevalence of chronic eye disease across Hispanic/Latino groups
using previously constructed HCHS/SOL “genetic analysis groups” (Mainland: Mexicans, Central and
South Americans; and, Caribbean: Cubans, Dominicans, and Puerto Ricans); and, 2) assess whether
prevalent disease is associated with novel CVD, biomedical, and sociocultural risk factors. Proposed
research leverages NHLBI-funded epidemiologic research supported by 6 other NIH Institutes, and represents
a significant opportun...

## Key facts

- **NIH application ID:** 10471195
- **Project number:** 5UG1EY030410-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** CHARLOTTE E JOSLIN
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,319,560
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10471195

## Citation

> US National Institutes of Health, RePORTER application 10471195, Study of Latinos (SOL) Ojos (5UG1EY030410-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10471195. Licensed CC0.

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