# University of Michigan O'Brien Kidney Translational Core Center

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $564,891

## Abstract

ABSTRACT – CENTER OVERVIEW
In order to rapidly develop effective therapies to prevent or reverse progression of chronic kidney disease
(CKD), the University of Michigan O'Brien Kidney Translational Core Center will support the full spectrum
of a translational pipeline providing resources to basic and clinical investigators in our Institutional and
International Research Bases using a 3-pronged approach:
 Expansion of our unique CKD cohort combined with its longitudinal tissue, urine and serum
 biobanks to allow our research base investigators to investigate the molecular causes and
 endpoints of chronic kidney diseases;
 Dissemination and support of the most modern and powerful systems biological approaches for
 research base investigators to help them effectively identify novel and robust biomarkers,
 endpoints and targets for diagnosis and treatment of CKD;
 Expert analysis and integration of cohort and systems data for our research base investigators
 through the use of sophisticated bioinformatics and database integration that promote
 identification of specific pathways and targets for treatments for individuals or groups of subjects
 with CKD.
The Center's aims are to:
 1) Expand translational and systems biological approaches to kidney disease research by
 expanding the Center's CKD deep clinical phenotyping and biobanking efforts through the Clinical
 Phenotyping and Resource Biobank Core (C-PROBE);
 2) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease
 research studies by our Institutional Research Core investigators through the use of sophisticated
 but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches
 through the Applied Systems Biology Core;
 3) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that
 accompany systems biological approaches to their functional implications regarding kidney
 disease development, diagnosis, progression and therapeutic potential through the Data Analytic
 Services Core (DASC);
 4) Expand worldwide outreach efforts via Nephroseq and tranSMART;
 5) Use the Kidney Educational Enrichment Programs and the Pilot and Feasibility Program to entice
 trainees and faculty into kidney research and support our research bases in their ongoing kidney
research.

## Key facts

- **NIH application ID:** 10471820
- **Project number:** 5P30DK081943-15
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Subramaniam Pennathur
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $564,891
- **Award type:** 5
- **Project period:** 2008-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10471820

## Citation

> US National Institutes of Health, RePORTER application 10471820, University of Michigan O'Brien Kidney Translational Core Center (5P30DK081943-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10471820. Licensed CC0.

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