# Next-generation human connectome atlas across the timespan of brain development

> **NIH NIH R01** · CHILDREN'S HOSP OF PHILADELPHIA · 2022 · $226,877

## Abstract

ABSTRACT 
The formation of a highly efficient and segregated connectome begins during the third trimester and develops throughout infancy, childhood, adolescence, and into adulthood. However, precise and comprehensive delineation of the development of the connectome – elucidating the neural connectome at multiple ages of human development - has been less well studied despite efforts made to assess the lifespan connectome. The human brain connectome is fundamentally underlaid by the cell-to-cell connections that comprise the functional circuitry and global network organization. Region-specific disruptions to neural connectivity may underlie neuropsychiatric disorders including schizophrenia and autism spectrum disorder. In this study, we will establish unique next-generation whole-brain connectomic atlas with connectomic data with resolution of isotropic 1mm or submillimeter during human infancy and childhood to gain hitherto unattainable insights into human brain development and neuropsychiatric disease. The developmental connectome atlas can be potentially associated with precise spatiotemporal patterns of gene expression that differentiate brain regions, cell types, and developmental periods. This atlas will be freely disseminated to the public through an integrated web portal.

## Key facts

- **NIH application ID:** 10471921
- **Project number:** 5R01MH125333-02
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** Hao Huang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $226,877
- **Award type:** 5
- **Project period:** 2021-08-20 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10471921

## Citation

> US National Institutes of Health, RePORTER application 10471921, Next-generation human connectome atlas across the timespan of brain development (5R01MH125333-02). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10471921. Licensed CC0.

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