# Washington University Rheumatic DiseasesResearch Resource-based Center

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2022 · $744,893

## Abstract

OVERALL ABSTRACT
 The overarching Goal of the Washington University Rheumatic Diseases Research Resource-based
Center (WU-RDRRC) is to advance research in rheumatic diseases by providing the infrastructure, resources
and opportunities for multiple levels of inquiry and translating those discoveries into treatments for delivery to
patients. The WU-RDRRC seeks to advance the health of patients with rheumatic disease by supporting
enabling technology and promoting the basic and translational research interests of its members. These
interests are organized around three major themes: (1) Basic mechanisms of inflammation and autoimmunity;
(2) Translational genomics and biomarker discovery; and (3) Musculoskeletal and Regenerative Medicine.
 Our Central Hypothesis is that translational endeavors in rheumatic diseases research require a team
approach performed in a vibrant environment supported by a cross-disciplinary team of experts and state-of-
the-art services. Our Focus is to promote interactive approaches that will accelerate the pace of innovative
discoveries and translate findings to improvements in treatments for patients with rheumatic diseases.
 To accomplish our goals we propose the following: 1) A Translational Research Core (TRC) that comprises
separate but related services devoted to supporting translational research endeavors: i) an integrated
rheumatic disease registry and biospecimen repository (Biobank) that can be searched through electronic
biomedical data management systems to allow annotation, tracking and sharing of tissue and databases; ii) a
Genomics & Bioinformatics Facility (GBF) powered by the most up-to-date Next-Generation Sequencing
technologies and bioinformatics tools to enhance the secure use and analysis of human genomic data and iii)
an ImmunoMonitoring Facility (IMF) that offers access to mass cytometry for analysis of human samples. 2) A
Genome Engineering Core (GEC) that facilitates functional studies through the use of technological advances
such as CRISPR/Cas9 to generate mutant cell lines and knockout/knock-in mice and induced Pluripotent Stem
Cells (iPSCs); and 3) A Cellular Imaging Core (CIC) that provides state-of-the-art imaging technologies for
building models of health and disease. The Administrative Core promotes collaborative and synergistic
interactions in rheumatic diseases research across multiple disciplines and fosters the mentoring of new
investigators interested in rheumatic disease-related research.

## Key facts

- **NIH application ID:** 10472003
- **Project number:** 5P30AR073752-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Deborah J Lenschow
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $744,893
- **Award type:** 5
- **Project period:** 2018-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10472003

## Citation

> US National Institutes of Health, RePORTER application 10472003, Washington University Rheumatic DiseasesResearch Resource-based Center (5P30AR073752-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10472003. Licensed CC0.

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