# Translational Research Core

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2022 · $247,172

## Abstract

TRANSLATIONAL RESEARCH CORE ABSTRACT 
The overarching goal for the Translational Research Core is to promote, facilitate and accelerate translational 
science by providing the infrastructure, training and resources to support the investigators of Washington 
University Rheumatic Diseases Research Resource-based Center (WU-RDRRC) in their research endeavors. 
The highly trained TRC team will work closely with WU-RDRRC members in the design of clinical/translational 
studies, aid in the development of research protocols, help navigate institutional review board (IRB) 
requirements, assist in the collection or use of biospecimens, and facilitate access to high quality downstream 
analysis using genomics, bioinformatics, or immunophenotyping. In brief, the TRC team will guide 
investigators from concept development to genomic discovery with the ultimate goal of disseminating 
and/or translating the findings to practice. Towards these goals we will pursue the following Aims: 
 1. Develop an integrated rheumatic diseases Registry and biospecimens Repository (Biobank) that can be 
 searched/maintained through electronic biomedical data management systems, allowing for the 
 annotation, tracking, and sharing of tissue and databases. The Biobank maintains i) an open IRB 
protocol, allowing the broad collection of biospecimens linked to clinical data; ii) trained personnel to 
maintain IRB protocols and assist investigators in the submission of amended protocols for expedited 
review, recruit/enroll patients, collect/process specimens; iii) best biobanking practices for the archival 
 of high quality biospecimens to be used in the initial or future studies by WU-RDRRC members. 
2. Provide a Genomics & Bioinformatics Facility (GBF) powered by the most up-to-date Next-Generation 
 Sequencing (NGS) technologies, including single cell sequencing, and sophisticated bioinformatics 
 tools to enhance the secure use and analysis of human genomics data. 
3. Provide an ImmunoMonitoring Facility (IMF) that offers training and access to mass cytometry as well 
 as several panels of validated custom-designed metal-conjugated CyTOF-ready antibodies and 
 tetramers that are currently not available commercially.

## Key facts

- **NIH application ID:** 10472005
- **Project number:** 5P30AR073752-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Wayne M. Yokoyama
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $247,172
- **Award type:** 5
- **Project period:** 2018-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10472005

## Citation

> US National Institutes of Health, RePORTER application 10472005, Translational Research Core (5P30AR073752-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10472005. Licensed CC0.

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