# Genome Engineering Core

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2022 · $182,011

## Abstract

GENOME ENGINEERING CORE ABSTRACT
The goal of the Genome Engineering Core of the Washington University Rheumatic Diseases Research
Resource-based Center (WU-RDRRC) is to provide access to innovative genomic technologies to facilitate
modeling and investigation of human rheumatic disease by WU-RDRRC investigators. Genomic investigation
of the basis of rheumatic disease has become widespread, including genome-wide association studies
(GWAS), whole exome and genome sequencing, and epigenetic profiling. However, the translation of genetic
findings can be challenging, often requiring validation in unique model systems. Development of such models
is now possible with state-of-the-art genome engineering technologies. These technologies, such as
development of genetically-engineered mice and CRISPR/Cas9 editing of induced pluripotent stem cells
(iPSCs) require significant experience and, in some cases highly-specialized equipment not available within
most laboratories. We propose to support the ability of WU-RDRRC members to utilize the latest in genomic
engineering techniques by leveraging services from the Transgenic and Knockout Mouse Facility (TKMF) and
the Genome Engineering and iPSC Center (GEiC). Towards this end we propose the following Specific Aims:
 1. Sustain, develop, and introduce new state-of-the-art genetics services to WU-RDRRC members.
 2. Assist investigators in the generation of genetically engineered mouse models by partnering with the
 Transgenic and Knockout Mouse Facility (TKMF).
 3. Assist investigators in the generation of CRISPR reagents for genetically-engineered mice and creation
 of genetically-engineered cell lines and stem cells including iPSCs by leveraging the Genome
 Engineering and iPSC Center (GEiC).

## Key facts

- **NIH application ID:** 10472006
- **Project number:** 5P30AR073752-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Farshid Guilak
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $182,011
- **Award type:** 5
- **Project period:** 2018-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10472006

## Citation

> US National Institutes of Health, RePORTER application 10472006, Genome Engineering Core (5P30AR073752-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10472006. Licensed CC0.

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