# Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

> **NIH NIH T32** · JOHNS HOPKINS UNIVERSITY · 2022 · $388,919

## Abstract

Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States
and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital
heart disease surgery and other infants and children with critical heart and lung disorders including those children
with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung
disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling
need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This
renewal proposal describes a multidisciplinary training program to prepare clinician-scientists who are in
subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously
trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung
disease. The program is supported by faculty who are experts in laboratory, clinical and translational research,
including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics,
proteomics and biomarkers, computational medicine, imaging, clinical trials and clinical implementation and
safety research. The environment provides many opportunities for trainees by virtue of superb centers, core
facilities and programs in which faculty participate such as NHLBI supported clinical trials, the Armstrong Institute
for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two research tracts
are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for
physician scientists with an emphasis on translational research. B. Clinical investigation supported by the
Graduate Training Program in Clinical Investigation, which may include clinical implementation research which
is vitally important in critical care fields. Each of four trainees in the program will have an individual development
plan program that is created in consultation with a Steering Committee, a primary mentor and mentorship
team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic
groups with leadership from a member of the Pediatric Department diversity committee, and training in the
responsible conduct of research. At the conclusion of the program, the trainees will be well prepared to transition
towards positions in academic pediatric cardiology and intensive care fields developing funded independent
research careers.

## Key facts

- **NIH application ID:** 10472485
- **Project number:** 5T32HL125239-08
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Melania Maria Bembea
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $388,919
- **Award type:** 5
- **Project period:** 2015-02-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10472485

## Citation

> US National Institutes of Health, RePORTER application 10472485, Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease (5T32HL125239-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10472485. Licensed CC0.

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