# Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage

> **NIH NIH DP2** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $1,404,000

## Abstract

PROJECT SUMMARY
My long-term goal is to reconstruct limbs that have lost function due to injury or disease. To achieve this goal,
my research program combines surgical and mechanical design in a paradigm called anatomics, in which body
and machine are co-engineered in pursuit of superior bionic performance. In this proposal, I apply an anatomics-
centered approach to the surgical treatment of limb pathology. The human body is made up of compliant
(“flexible”) structures that are fundamental to basic function. Joints, the highly-compliant structures that link
bones together, are perhaps the most important of these structures for human movement. The nuanced
relationships between load and deformation (called “compliance”) in joint tissues dictate how internal and
external forces are converted to limb motion. Disruption of inherent biological compliance is often devastating to
the body’s ability to move in a healthy way. This disruption can occur as a result of injury or disease, or even the
reconstructive procedures intended to alleviate limb pathology. In severe cases, the pain and disability caused
by changes to limb compliance are so intense, and treatment options so limited, that patients choose to amputate
their viable but dysfunctional limb in search of relief. Unfortunately, there is currently no way to correct the
compliance of biological joints and tissues when they are disrupted; this creates enormous challenges for the
increasing number of patients with limb pathology, who are often left to live with limbs that are viable but non-
functional. In response to this need, I propose a novel class of compliant implantable prostheses that would
enable pathological joint compliance to be corrected, and function restored. With support from the New Innovator
Award, I will advance a novel compliant limb reconstruction (CLR) pipeline capable of generating joint-and-
pathology-specific implant mechanics, and apply this pipeline to design implants for two limb pathologies with
urgent unmet clinical needs. I will then fabricate and validate these implants, collecting critical data to support
early feasibility studies in human subjects. This work will form the foundation for future initiatives supporting
refinement of the CLR pipeline, and is the first step toward a research program that uses the approach to target
many different pathologies across all of the body’s joints. I expect that the proposed research will transform the
clinical paradigm for treatment of limb pathology, opening the door to revolutionary new salvage options that
alleviate pain, restore function, and prevent amputation.

## Key facts

- **NIH application ID:** 10473072
- **Project number:** 1DP2HD111538-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Tyler R Clites
- **Activity code:** DP2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,404,000
- **Award type:** 1
- **Project period:** 2022-09-10 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10473072

## Citation

> US National Institutes of Health, RePORTER application 10473072, Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage (1DP2HD111538-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10473072. Licensed CC0.

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