# Bridge2AI: Cell Maps for AI (CM4AI) Data Generation Project

> **NIH NIH OT2** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $4,894,457

## Abstract

As part of the NIH Common Fund’s Bridge2AI program, the CM4AI data generation 
project seeks to map the spatiotemporal architecture of human cells and use these 
maps toward the grand challenge of interpretable genotype-phenotype learning. In 
genomics and precision medicine, machine learning models are often "black boxes," 
predicting phenotypes from genotypes without understanding the mechanisms by 
which such translation occurs. To address this deficiency, project will launch a 
coordinated effort involving three complementary mapping approaches – proteomic 
mass spectrometry, cellular imaging, and genetic perturbation via CRISPR/Cas9 –
creating a library of large-scale maps of cellular structure/function across 
demographic and disease contexts. These data will broadly stimulate research and 
development in "visible" machine learning systems informed by multi-scale cell and 
tissue architecture. In addition to data and tools, this project will implement a 
standards data management approach based on FAIR access and software principles, 
with deep provenance and replication packages for representation of cell maps and 
their underlying datasets; initiate a research program in ethical AI, especially as it 
relates to how maps will be used in genomic medicine and model interpretation; and 
stimulate a diverse portfolio of training opportunities in the emerging field of 
biomachine learning.

## Key facts

- **NIH application ID:** 10473403
- **Project number:** 1OT2OD032742-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Jean-Christophe Bélisle-Pipon
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $4,894,457
- **Award type:** 1
- **Project period:** 2022-09-01 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10473403

## Citation

> US National Institutes of Health, RePORTER application 10473403, Bridge2AI: Cell Maps for AI (CM4AI) Data Generation Project (1OT2OD032742-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10473403. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*